abstract：:Several studies report that the OPG is an important candidate gene in the pathogenesis of osteoporosis. This study aimed to detect the potential association of OPG gene polymorphisms with osteoporosis in postmenopausal women. We recruited 928 subjects containing 463 with primary postmenopausal osteoporosis and 465 hea...

journal_title：BioMed research international

authors： Wang F,Cao Y,Li F,Shan J,Wen T

更新日期：2014-01-01 00:00:00

abstract：:Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...

journal_title：BioMed research international

authors： Amaya-Amaya J,Montoya-Sánchez L,Rojas-Villarraga A

更新日期：2014-01-01 00:00:00

abstract：:Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...

journal_title：BioMed research international

authors： Pyshnaya IA,Razum KV,Poletaeva JE,Pyshnyi DV,Zenkova MA,Ryabchikova EI

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To determine the predictive factors that affect short term and long term postoperative drift in intermittent exotropia after bilateral lateral rectus recession and to evaluate its effect on surgical outcome. METHODS:Retrospective review of 203 patients with diagnosis of intermittent exotropia, who had surgical...

journal_title：BioMed research international

authors： Yam JC,Chong GS,Wu PK,Wong US,Chan CW,Ko ST

更新日期：2014-01-01 00:00:00

abstract：:A potent fibrinolytic enzyme-producing Bacillus cereus IND1 was isolated from the Indian food, rice. Solid-state fermentation was carried out using agroresidues for the production of fibrinolytic enzyme. Among the substrates, wheat bran supported more enzyme production and has been used for the optimized enzyme produc...

journal_title：BioMed research international

authors： Vijayaraghavan P,Vincent SG

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation ...

journal_title：BioMed research international

authors： Ou JR,Tan MS,Xie AM,Yu JT,Tan L

更新日期：2014-01-01 00:00:00

abstract：:We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming. Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in r...

journal_title：BioMed research international

authors： Khot V,Kale A,Joshi A,Chavan-Gautam P,Joshi S

更新日期：2014-01-01 00:00:00

abstract：:The incidence of acute kidney injury induced by contrast media (CI-AKI) is the third cause of AKI in hospitalized patients. Contrast media cause relevant alterations both in renal hemodynamics and in renal tubular cell function that lead to CI-AKI. The vasoconstriction of intrarenal vasculature is the main hemodynamic...

journal_title：BioMed research international

authors： Caiazza A,Russo L,Sabbatini M,Russo D

更新日期：2014-01-01 00:00:00

abstract：:Due to expanding applications of positron emission tomography (PET) there is a demand for developing new techniques to introduce fluorine-18 (t 1/2 = 109.8 min). Considering that most novel PET tracers are sensitive biomolecules and that direct introduction of fluorine-18 often needs harsh conditions, the insertion of...

journal_title：BioMed research international

authors： Kettenbach K,Schieferstein H,Ross TL

更新日期：2014-01-01 00:00:00

abstract：:Abdominal pregnancy is a very rare form of ectopic pregnancy, associated with high morbidity and mortality for both fetus and mother. It is, and often, seen in poor resource nations, where early diagnosis is often a major challenge due to poor prenatal care and lack of medical resources. An advanced abdominal pregnanc...

journal_title：BioMed research international

authors： Dabiri T,Marroquin GA,Bendek B,Agamasu E,Mikhail M

更新日期：2014-01-01 00:00:00

abstract：:Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...

journal_title：BioMed research international

authors： Ching XT,Lau YL,Fong MY,Nissapatorn V,Andiappan H

更新日期：2014-01-01 00:00:00

abstract：:Legumes have developed a unique way to interact with bacteria: in addition to preventing infection from pathogenic bacteria like any other plant, legumes also developed a mutualistic symbiotic relationship with one gender of soil bacteria: rhizobium. This interaction leads to the development of a new root organ, the n...

journal_title：BioMed research international

authors： Libault M

更新日期：2014-01-01 00:00:00

abstract：:We undertook an investigation to advance understanding of the host-range dynamics and biocontrol implications of Cochliobolus lunatus in the past decade. Potato (Solanum tuberosum L) farms were routinely surveyed for brown-to-black leaf spot disease caused by C. lunatus. A biphasic gene data set was assembled and data...

journal_title：BioMed research international

authors： Louis B,Waikhom SD,Roy P,Bhardwaj PK,Sharma CK,Singh MW,Talukdar NC

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism. METHODS:Four hundred women with normal pregnancies were enrolled in this study. SNPs were identified by MassARRAY. Serum folic acid and Hcy concentration were me...

journal_title：BioMed research international

authors： Liang S,Zhou Y,Wang H,Qian Y,Ma D,Tian W,Persaud-Sharma V,Yu C,Ren Y,Zhou S,Li X

更新日期：2014-01-01 00:00:00

abstract：:Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediter...

journal_title：BioMed research international

authors： Karygianni L,Cecere M,Skaltsounis AL,Argyropoulou A,Hellwig E,Aligiannis N,Wittmer A,Al-Ahmad A

更新日期：2014-01-01 00:00:00

abstract：:Oyster mushroom Pleurotus florida was cultivated on different combinations of wheat straw (WS) as basal substrate and oyster shell powder (OSP) supplement. The OSP supplementation considerably responded to different cultivation phases. The mycelium grew fast and showed rapid growth rate (8.91 mmd(-1)) in WS + OSP (97 ...

journal_title：BioMed research international

authors： Naraian R,Narayan OP,Srivastava J

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF THE REPORT:There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis. MATERIALS AND METHODS:We prospectively analyzed a coh...

journal_title：BioMed research international

authors： Barik M,Bajpai M,Das RR,Malhotra A,Panda SS,Sahoo MK,Dwivedi S

更新日期：2014-01-01 00:00:00

abstract：:We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions. Male Wistar rats were divided into four groups: control (CON), diabetic (DM; streptozotocin (STZ), i.v. 55 mg/kg BW), control-treated with cu...

journal_title：BioMed research international

authors： Wongeakin N,Bhattarakosol P,Patumraj S

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Noncardiac chest pain (NCCP) is seen more frequently in young population and in these patients loss of function is evolving in social and professional areas. The aim of the study is to evaluate the levels of anxiety and somatic perception in patients with chest pain presenting to cardiology clinic. METHODS:F...

journal_title：BioMed research international

authors： Zincir SB,Sunbul M,Sunbul EA,Dalkilic B,Cengiz F,Kivrak T,Durmus E

更新日期：2014-01-01 00:00:00

abstract：:The aim of the study was to assess the prevalence of temporomandibular disorders (TMD) and oral parafunctions, as well as their correlation with psychoemotional factors in Polish university students. The research was conducted in a group of 456 students (N = 456). The examination form comprised of two parts: survey an...

journal_title：BioMed research international

authors： Wieckiewicz M,Grychowska N,Wojciechowski K,Pelc A,Augustyniak M,Sleboda A,Zietek M

更新日期：2014-01-01 00:00:00

abstract：:The chromosomal changes accompanying bivalve evolution are an area about which few reports have been published. To improve our understanding on chromosome evolution in Veneridae, ribosomal RNA gene clusters were mapped by fluorescent in situ hybridization (FISH) to chromosomes of five species of venerid clams (Venerup...

journal_title：BioMed research international

authors： Pérez-García C,Hurtado NS,Morán P,Pasantes JJ

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:(1) To evaluate a new acquisition protocol of (18)F-choline (FCH) PET/CT for prostate cancer patients (PC), (2) to review acquisition (18)F-choline PET/CT methodology, and (3) to propose a standardized acquisition protocol on FCH PET/CT in PC patients. MATERIALS:100 consecutive PC patients (mean age 70.5 years...

journal_title：BioMed research international

authors： Chondrogiannis S,Marzola MC,Grassetto G,Maffione AM,Rampin L,Veronese E,Massaro A,Rubello D

更新日期：2014-01-01 00:00:00

abstract：:In the present study aortic murine smooth muscle cell (SMC) antigen presentation capacity was evaluated using the Eα-GFP/Y-Ae system to visualize antigen uptake through a GFP tag and tracking of Eα peptide/MHCII presentation using the Y-Ae Ab. Stimulation with IFN-γ (100 ng/mL) for 72 h caused a significant (P < 0.01)...

journal_title：BioMed research international

authors： Maddaluno M,MacRitchie N,Grassia G,Ialenti A,Butcher JP,Garside P,Brewer JM,Maffia P

更新日期：2014-01-01 00:00:00

abstract：:Brachial plexus injury often involves traumatic root avulsion resulting in permanent paralysis of the innervated muscles. The lack of sufficient regeneration from spinal motoneurons to the peripheral nerve (PN) is considered to be one of the major causes of the unsatisfactory outcome of various surgical interventions ...

journal_title：BioMed research international

authors： Su H,Yuan Q,Qin D,Yang X,Wong WM,So KF,Wu W

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have bee...

journal_title：BioMed research international

authors： Jia Q,Deng Y,Qing H

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The primary aim of this study was to explore if classification, whether using the BI-RADS categories based on CEUS or conventional ultrasound, was conducive to the identification of benign and malignant category 3 or 4 small breast lesions. MATERIAL AND METHODS:We evaluated 30 malignant and 77 benign small bre...

journal_title：BioMed research international

authors： Zhang JX,Cai LS,Chen L,Dai JL,Song GH

更新日期：2014-01-01 00:00:00

abstract：:Apolipoprotein E4 (Apo E4) is the major genetic risk factor in the causation of Alzheimer's disease (AD). In this study we utilize virtual screening of the world's largest traditional Chinese medicine (TCM) database and investigate potential compounds for the inhibition of ApoE4. We present the top three TCM candidate...

journal_title：BioMed research international

authors： Huang HJ,Chen HY,Lee CC,Chen CY

更新日期：2014-01-01 00:00:00

abstract：:Picobirnavirus (PBV) which has been included in the list of viruses causing enteric infection in animals is highly versatile because of its broad host range and genetic diversity. PBVs are among the most recent and emerging small, nonenveloped viruses with a bisegmented double-stranded RNA genome, classified under a n...

journal_title：BioMed research international

authors： Malik YS,Kumar N,Sharma K,Dhama K,Shabbir MZ,Ganesh B,Kobayashi N,Banyai K

更新日期：2014-01-01 00:00:00

abstract：:To overcome the issues connected to the use of autologous vascular grafts and artificial materials for reconstruction of small diameter (<6 mm) blood vessels, this study aimed to develop acellular matrix- (AM-) based vascular grafts. Rat iliac arteries were decellularized by a detergent-enzymatic treatment, whereas en...

journal_title：BioMed research international

authors： Dall'Olmo L,Zanusso I,Di Liddo R,Chioato T,Bertalot T,Guidi E,Conconi MT

更新日期：2014-01-01 00:00:00

abstract：:Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with ...

journal_title：BioMed research international

authors： Gaur PK,Mishra S,Bajpai M,Mishra A

更新日期：2014-01-01 00:00:00

abstract：:Carbonic anhydrases (CAs) are enzymes that catalyse the reversible hydration of CO2 to bicarbonate. CA XII is considered a potential biomarker of tumor cells and a promising target for specific therapies. The aim of the current study was to develop new monoclonal antibodies (MAbs) against human recombinant CA XII and ...

journal_title：BioMed research international

authors： Dekaminaviciute D,Lasickiene R,Parkkila S,Jogaite V,Matuliene J,Matulis D,Zvirbliene A

更新日期：2014-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This stu...

journal_title：BioMed research international

authors： Zhao Z,Lu J,Jia X,Chao W,Han Y,Jia J,Li K

更新日期：2014-01-01 00:00:00

abstract：:Background and Purposes. The 320-detector row CT scanner enables visualization of whole-brain hemodynamic information (dynamic CT angiography (CTA) derived from CT perfusion scans). However, arterial image quality in dynamic CTA (dCTA) is inferior to arterial image quality in standard CTA. This study evaluates whether...

journal_title：BioMed research international

authors： Ghariq E,Mendrik AM,Willems PW,Joemai RM,Ghariq E,Vonken EJ,van Osch MJ,van Walderveen MA

更新日期：2014-01-01 00:00:00

abstract：:The availability of fluorescent dyes and the advances in the optical systems for in vivo imaging have stimulated an increasing interest in developing new methodologies to study and quantify the biodistribution of labeled agents. However, despite these great achievements, we are facing significant challenges in determi...

journal_title：BioMed research international

authors： Munisso MC,Yamaoka T

更新日期：2014-01-01 00:00:00

abstract：:Two field isolates of Rhizoctonia solani were isolated from infected paddy plants in Malaysia. These isolates were verified via ITS-rDNA analysis that yielded ~720 bp products of the ITS1-5.8S-ITS4 region, respectively. The sequenced products showed insertion and substitution incidences which may result in strain dive...

journal_title：BioMed research international

authors： Nadarajah K,Omar NS,Rosli MM,Shin Tze O

更新日期：2014-01-01 00:00:00

abstract：:TMJ disc related diseases are difficult to be cured due to the poor repair ability of the disc. TMJ-SDSCs were ideal cell sources for cartilage tissue engineering which have been widely used in hyaline cartilage regeneration. Fibrin gel has been demonstrated as a potential scaffold for neocartilage formation. The aim ...

journal_title：BioMed research international

authors： Wu Y,Gong Z,Li J,Meng Q,Fang W,Long X

更新日期：2014-01-01 00:00:00

abstract：:A novel methylamine-selective amperometric bienzyme biosensor based on recombinant primary amine oxidase isolated from the recombinant yeast strain Saccharomyces cerevisiae and commercial horseradish peroxidase is described. Two amine oxidase preparations were used: free enzyme (AMO) and covalently immobilized on the ...

journal_title：BioMed research international

authors： Stasyuk NY,Smutok OV,Zakalskiy AE,Zakalska OM,Gonchar MV

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Recently antiangiogenic therapy with bevacizumab has shown a high but transient efficacy in glioblastoma (GBM). Indeed, GBM is one of the most angiogenic human tumors and endothelial proliferation is a hallmark of the disease. We therefore hypothesized that tumor cells may participate in endothelial prolifer...

journal_title：BioMed research international

authors： El Hallani S,Colin C,El Houfi Y,Idbaih A,Boisselier B,Marie Y,Ravassard P,Labussière M,Mokhtari K,Thomas JL,Delattre JY,Eichmann A,Sanson M

更新日期：2014-01-01 00:00:00

abstract：:We developed a new product called titanium-prepared platelet-rich fibrin (T-PRF). The T-PRF method is based on the hypothesis that titanium may be more effective in activating platelets than the silica activators used with glass tubes in Chouckroun's leukocyte- and platelet-rich fibrin (L-PRF) method. In this study, w...

journal_title：BioMed research international

authors： Tunalı M,Özdemir H,Küçükodacı Z,Akman S,Yaprak E,Toker H,Fıratlı E

更新日期：2014-01-01 00:00:00

abstract：:To establish a reliable isoproterenol induced heart dysfunction fetal rat model and understand the switches of contractile proteins, 45 pregnant rats were divided into 15 mg/kg-once, 15 mg/kg-twice, sham-operated once, sham-operated twice, and control groups. And 18 adult rats were divided into isoproterenol-treated a...

journal_title：BioMed research international

authors： Li Y,Fang J,Hua Y,Wang C,Mu D,Zhou K

更新日期：2014-01-01 00:00:00